Mathematica is working with federal, state, and local governments as well as foundations and research organizations to help combat the opioid epidemic. Our researchers combine advanced analytic methods with in-depth knowledge of substance abuse and mental health service delivery to help policymakers monitor and react to changes in opioid misuse. We also apply economic and epidemiologic principles to better recognize unintended consequences and long-term ramifications of interventions intended to reduce opioid use.